Frank Curzio
By Frank CurzioDecember 19, 2016

Ep. 472: Frankly Speaking: How to invest in small-cap biotech stocks

Welcome back to another episode of Frankly Speaking!

On today’s show, I open up by breaking down the small-cap biotech sector. Jeff provides listeners with a perfect example of a biotech stock fighting for FDA approval.

I’ve seen this happen too many times…

From the pre-clinical stages… all the way through the approval process… these companies undertake extreme volatility. Step-by-step, I explain the lengthy process every small-cap biotech company must endure. In addition, I tell listeners exactly when it’s the best time to place their bets on these types of investments.

Then, after revisiting my position on Northern Dynasty (NAK), I dive into a very important lesson… Stop-loss orders. This is an investment tool every investor must use in order to prevent large portfolio deficits.

I often warn investors to not “show their hand”… Tune in to hear what I mean.

Finally, to end the episode, I dive into another sector that has just about topped-out. With interest rates going higher, I tell listeners why I’m avoiding this market going forward.

Special thanks to Brain, Jeff, Kenny, Craig, and Steve for all the great questions… Keep them coming!

Thanks for listening,

Frank Curzio

Stocks Mentioned:

What’s really moving these markets?
Subscribe to access daily market updates and exclusive content
More about Podcast
2026

These sectors are poised for major upside in 2026

Frank's favorite plays on AI, Big Tech, rising oil prices, and more. Plus, the CPI paves the way for rate cuts… Trump's plans to reignite the economy… Ford (F) is quitting EVs… And a rare opportunity in a hospitality disruptor.

Katie Stockton, Fairlead Strategies

Are we in an “AI-or-bust” market?

Katie Stockton, founder and managing partner of Fairlead Strategies, breaks down whether we're in an "AI-or-bust" market… her step-by-step process for finding winners… the sectors she's watching closely in 2026… and much more.

The Fed just quietly confirmed QE is back

Key takeaways from the Fed meeting: Quantitative easing is back. Plus, Disney's (DIS) OpenAI partnership… Why Oracle (ORCL) is tanking… Steve Eisman on what could shrink AI demand… And 3 reasons this small AI stock is poised to surge.

Sectors set to surge in 2026

3 sectors set to surge in 2026

Interest rates are going down—regardless of the Fed… and these 3 sectors will profit as bond yields steepen. Plus, 2 housing stocks to buy… The real winner in Trump's China chip deal… And the Warner Bros. (WBD) bidding war.

More from Frank Curzio
Bitcoin

Bitcoin is getting ready for a rebound

Bitcoin (BTC) is getting close to a bottom—and a simple trade to profit. Plus, Jim Cramer and big banks… Why Netflix (NFLX) won't win the Warner Bros. (WBD) bid… Disney's (DIS) "power" move… And power stocks to buy on the…

Michel Amar, Digi Power X

Why DGXX could surge over 500%

Michel Amar, CEO of DigiPower X (DGXX), breaks down the stock's incredible six-month rise… how the company's Supermicro (SMCI) partnership will drive massive growth… and why DGXX's market cap could soar from $250M to over $2B.

Google’s new chips: Is Nvidia in trouble?

Will Alphabet (GOOG) dethrone Nvidia (NVDA) with its new chips? Plus, what Dell's (DELL) earnings prove about the AI trend… The best spinoff ever… Why is Bitcoin (BTC) in a freefall? … JPMorgan's (JPM) debanking mistake… And forecasts for 2026.

AI

NVDA just debunked the ‘AI bubble’ myth

Nvidia's (NVDA) earnings: Key takeaways. Plus, investing in collectibles… This energy infrastructure play is a steal… Time to throw in the towel on Target (TGT)? … 13Fs… The downside of Berkshire's (BRK.A) balance sheet… And an ecommerce dumpster fire.

3 reasons to buy this market pullback

3 catalysts that will send stocks surging within six months. Plus, what to expect from Nvidia's (NVDA) earnings… Ford's (F) CEO just issued a major warning on the workforce… And is Berkshire (BRK.A) still relevant without Buffett?